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FOXA2 Antibody (701698) in ICC/IF
Immunofluorescence was performed on methanol fixed HepG2 cells for detection of FOXA2 using FOXA2 Recombinant Rabbit Monoclonal Antibody (Product # 701698, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Cytoskeleton was stained with alpha-Tubulin Monoclonal Antibody (Product # 32-2500, 1 µg/mL) followed by Goat anti-Mouse IgG Secondary Antibody, Alexa Fluor® 594 conjugate (Product # A-11032, 1:400). Panel a) shows representative cells that... View More
产品信息
701698
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
9H5L7
抗原
Protein corresponding to Human FOXA2 (aa 236-451)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2576439
产品详细信息
This antibody is predicted to react with Monkey, Horse, Cat and Dog.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; MGC19807; RONU; TCF-3B; Transcription factor 3B; WHN
基因别名: FOXA2; HNF3B; TCF3B
UniProt ID: (Human) Q9Y261
Entrez Gene ID: (Human) 3170
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
protein domain specific binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
positive regulation of transcription from RNA polymerase II promoter by glucose
negative regulation of transcription from RNA polymerase II promoter by glucose
cell fate specification
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
adult locomotory behavior
negative regulation of epithelial to mesenchymal transition
covalent chromatin modification
regulation of blood coagulation
endocrine pancreas development
negative regulation of glucokinase activity
positive regulation of embryonic development
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin secretion involved in cellular response to glucose stimulus
response to interleukin-6
dopaminergic neuron differentiation
primitive streak formation
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of gastrulation
negative regulation of detection of glucose
