Invitrogen

FOXC1 Polyclonal Antibody

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FOXC1 Antibody (PA5-68774) in WB

Western blot was performed using Anti-FOXC1 Polyclonal Antibody (Product # PA5-68774) and a 56.7 kDa band corresponding to FOXC1 was observed across all cell lines tested, except MCF10A and MIA PaCa-2. whole cell extracts (40 µg lysate) of Hep G2 (Lane 1), Hep G2 treated with IL-8 (50 ng/mL, 24hrs) (Lane 2), A549 (Lane 3), MCF10A (Lane 4), MIA PaCa-2 (Lane 5) were electrophoresed using NuPAGE™10% Bis-Tris Protein Gel (Product # NP0301BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® ... View More

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FOXC1 Antibody — Altered expression of proteins upon cell treatment demonstrates antibody specificity. Western blot using FOXC1 Polyclonal Antibody (Product # PA5-68774), shows an increase in expression of FOXC1 in Hep G2 upon IL-8 treatment. {TM}

产品信息

PA5-68774

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1.0 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the n terminal region of mouse FOXC1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2688802

产品详细信息

This target displays homology in the following species: Cow: 86%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%

靶标信息

FOXC1 is a protein belonging to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this protein is not known, however, it plays a role in the regulation of FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye. Mutations in this gene cause various glaucoma, iridogoniodysgenesis anomaly, Peters anomaly that includes central corneal leukoma, absence of the posterior corneal stroma and Descemetmembrane and Axenfeld-Rieger anomaly characterized by posterior corneal embryotoxon, iris adhesion to the Schwalbe line, hypertelorism, hypoplasia of the malar bones, congenital absence of some teeth and mental retardation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: congenital hydrocephalus; Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3; HGNC:3800; Mesoderm/mesenchyme forkhead 1; MF-1; Transcription factor FKH-1

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基因别名: ch; fkh-1; Fkh1; Fkhl7; Foxc1; FREAC3; frkhda; Mf1; Mf4

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UniProt ID: (Mouse) Q61572

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Entrez Gene ID: (Mouse) 17300

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功能

RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor binding DNA binding, bending sequence-specific DNA binding transcription regulatory region DNA binding winged helix/forkhead transcription factor

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