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FOXC2 Antibody (PA5-18172) in WB
Western blot analysis of FOXC2 using FOXC2 Polyclonal Antibody (Product # PA5-18172) (2 µg/mL) in staining of nuclear HEK293 (A) and (1 µg/mL) negative control Human Pancreas (B) lysate [RIPA buffer, 35 µg total protein per lane). Detected by chemiluminescence.
产品信息
PA5-18172
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (RHAAPYSYDCTKY) corresponding to the C-terminus amino acids of FOXC2 (aa 489-501).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10982836
产品详细信息
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
靶标信息
Forkhead box protein C2 (FOXC2) is a transciptional activator and is characterized by a distinct DNA-binding forkhead domain. FOXC2 may be involved in the formation of special mesenchymal tissues. Mutations affecting the gene can cause lymphedema-distichiasis (LYD).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: forkhead box C2 (MFH-1, mesenchyme forkhead 1); Forkhead box protein C2; forkhead, Drosophila, homolog-like 14; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; mesenchyme forkhead 1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; Transcription factor FKH-14
基因别名: FKHL14; FOXC2; LD; MFH-1; MFH1
UniProt ID: (Human) Q99958
Entrez Gene ID: (Human) 2303
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
chromatin DNA binding
identical protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
ossification
patterning of blood vessels
metanephros development
ureteric bud development
somitogenesis
lymphangiogenesis
blood vessel remodeling
transcription from RNA polymerase II promoter
Notch signaling pathway
mesoderm development
heart development
insulin receptor signaling pathway
response to hormone
positive regulation of endothelial cell migration
neural crest cell development
collagen fibril organization
positive regulation of cell adhesion mediated by integrin
embryonic heart tube development
positive regulation of vascular wound healing
camera-type eye development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of organ growth
vascular endothelial growth factor receptor signaling pathway
paraxial mesodermal cell fate commitment
embryonic viscerocranium morphogenesis
artery morphogenesis
regulation of blood vessel size
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
glomerular endothelium development
glomerular visceral epithelial cell differentiation
glomerular mesangial cell development
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of apoptotic process involved in outflow tract morphogenesis
