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产品信息
PA5-85078
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human FOXL2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792227
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Pig (100%), Rabbit (100%), Bovine (100%).
Positive Control: mouse eye.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
FOXL2 is a winged helix/forkhead transcription factor that is highly conserved in human, goat, mouse, and certain aquatic species. Given its cross-species conservation, it appears to play a critical role evolutionarily, likely in ovarian differentiation in mammals and in ovarian somatic cell differentiation and in further follicle development and/or maintenance. Immunohistochemical data shows that FOXL2 is a nuclear protein specifically expressed in eyelids and in fetal and adult ovarian follicular cells. It does not undergo any major posttranslational modifications. FOXL2 is also found to be associated with blepharo-phimosis/ptosis/epicanthus inverses syndrome (BPES). There are two forms of BPES. Type I BPES shows eyelid abnormal-ities that are associated with ovarian failure. In type II BPES, only eyelid defects are found. Studies have shown that FOXL2 is expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Blepharophimosis; epicanthus inversus; Forkhead box protein L2; forkhead transcription factor FOXL2; LUSTR2; MGC14393; P-Frk; Pituitary forkhead factor; putative transcription factor foxl2
基因别名: AU045128; BPES; BPES1; FOXL2; PFRK; PINTO; POF3
UniProt ID: (Human) P58012, (Mouse) O88470
Entrez Gene ID: (Human) 668, (Mouse) 26927
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
estrogen receptor binding
ubiquitin conjugating enzyme binding
cysteine-type endopeptidase regulator activity involved in apoptotic process
sequence-specific DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
ovarian follicle development
oocyte growth
extraocular skeletal muscle development
apoptotic DNA fragmentation
transcription from RNA polymerase II promoter
single fertilization
female somatic sex determination
cell differentiation
positive regulation of luteinizing hormone secretion
menstruation
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of follicle-stimulating hormone secretion
embryonic eye morphogenesis
granulosa cell differentiation
uterus development
transcription, DNA-templated
regulation of transcription, DNA-templated
