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产品信息
PA5-36084
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the RPRSCTWPL of human FoxO1 (aa 19-27).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553362
产品详细信息
This antibody detects endogenous protein at a molecular weight of 70-82 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AF6q21 protein; Afxh; Fork head domain transcription factor AFX1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box O3A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O3; Forkhead box protein O4; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma-like 1; forkhead protein; forkhead protein 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; MGC120490; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
基因别名: 1110048B16Rik; 2010203A17Rik; AF6q21; AFX; AFX1; Afxh; AI876417; C76856; FKH1; FKHR; Fkhr1; Fkhr2; Fkhr3; FKHRL1; FKHRL1P2; FOXO1; FOXO1A; FOXO2; FOXO3; FOXO3A; FOXO4; MLLT7; RGD1561201
UniProt ID: (Human) Q12778, (Human) O43524, (Human) Q3KPF1, (Rat) G3V7R4, (Mouse) Q9R1E0, (Mouse) Q9WVH4, (Mouse) Q9WVH3
Entrez Gene ID: (Human) 2308, (Human) 2309, (Human) 4303, (Rat) 84482, (Mouse) 56458, (Mouse) 56484, (Rat) 294515, (Rat) 302415, (Mouse) 54601
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, transcription factor binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription coactivator binding
chromatin binding
protein binding
beta-catenin binding
ubiquitin protein ligase binding
sequence-specific DNA binding
protein phosphatase 2A binding
core promoter binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein kinase binding
chromatin DNA binding
transcription factor binding
enzyme binding
identical protein binding
negative regulation of transcription from RNA polymerase II promoter
ovulation from ovarian follicle
initiation of primordial ovarian follicle growth
antral ovarian follicle growth
oocyte maturation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of translation
apoptotic process
anatomical structure morphogenesis
cell differentiation
DNA damage response, signal transduction by p53 class mediator
cellular response to oxidative stress
glucose homeostasis
positive regulation of neuron apoptotic process
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neural precursor cell proliferation
regulation of reactive oxygen species metabolic process
cell cycle arrest
mitotic G2 DNA damage checkpoint
negative regulation of cell proliferation
insulin receptor signaling pathway
negative regulation of angiogenesis
stem cell differentiation
negative regulation of smooth muscle cell differentiation
negative regulation of G0 to G1 transition
blood vessel development
autophagy
cellular response to DNA damage stimulus
cellular response to starvation
positive regulation of autophagy
cellular response to insulin stimulus
negative regulation of stress-activated MAPK cascade
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of fat cell differentiation
positive regulation of gluconeogenesis
positive regulation of protein catabolic process
cellular response to hyperoxia
cellular response to nitric oxide
regulation of nucleic acid-templated transcription
tumor necrosis factor-mediated signaling pathway
temperature homeostasis
cellular glucose homeostasis
protein acetylation
endocrine pancreas development
fat cell differentiation
negative regulation of transcription, DNA-templated
enamel mineralization
cellular response to hydrogen peroxide
cellular response to cold
cellular response to dexamethasone stimulus
response to fluoride
regulation of energy homeostasis
cell cycle
multicellular organism development
muscle organ development
positive regulation of cell cycle arrest
