Invitrogen

FSHR Polyclonal Antibody

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FSHR Antibody (PA5-50963) in WB

Drug design, development and therapy 2021 - Figure 4 Protein analysis of ovarian FSHR and AMH in different groups. ( A ) Immunohistochemistry analysis of ovary sections in different groups. ( B ) and ( C ) are quantitative analysis of the positive stained part in follicles. ( D ) Images of the Western-blot results in different groups. ( E ) and ( F ) are quantitative analysis of the blot bands. *: P<0.05 compared with C group, #: P<0.05 compared with... View More

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产品信息

PA5-50963

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看4篇已发表文章 4篇已发表文章

免疫组化 (IHC)

1:100-1:300

查看2篇已发表文章 2篇已发表文章

免疫细胞化学 (ICC/IF)

1:200-1:1,000

酶联免疫吸附实验 (ELISA)

1:5,000

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from the Internal region of human FSHR.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2636411

产品详细信息

FSH Receptor / FSHR Polyclonal Antibody detects endogenous levels of FSH Receptor / FSHR protein.

靶标信息

Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

FSH blockade improves cognition in mice with Alzheimer's disease.

Nature

Xiong J,Kang SS,Wang Z,Liu X,Kuo TC,Korkmaz F,Padilla A,Miyashita S,Chan P,Zhang Z,Katsel P,Burgess J,Gumerova A,Ievleva K,Sant D,Yu SP,Muradova V,Frolinger T,Lizneva D,Iqbal J,Goosens KA,Gera S,Rosen CJ,Haroutunian V,Ryu V,Yuen T,Zaidi M,Ye K

PA5-50963 was used in Immunohistochemistry and Western Blotting to suggest a causal role for rising serum FSH levels in the exaggerated Alzheimer's disease pathophysiology during menopause, but also reveal an opportunity for treating Alzheimer's disease, obesity, osteoporosis and dyslipidaemia with a single FSH-blocking agent.

Tue Mar 01 00:00:00 UTC 2022

FSH blockade improves cognition in mice with Alzheimer's disease.

Nature

Tue Mar 01 00:00:00 UTC 2022

Brain atlas for glycoprotein hormone receptors at single-transcript level.

eLife

Ryu V,Gumerova A,Korkmaz F,Kang SS,Katsel P,Miyashita S,Kannangara H,Cullen L,Chan P,Kuo T,Padilla A,Sultana F,Wizman SA,Kramskiy N,Zaidi S,Kim SM,New MI,Rosen CJ,Goosens KA,Frolinger T,Haroutunian V,Ye K,Lizneva D,Davies TF,Yuen T,Zaidi M

PA5-50963 was used in Immunohistochemistry to create a comprehensive neuroanatomical atlas on the expression of TSHR, LHCGR, and FSHR.

Fri Sep 02 00:00:00 UTC 2022

Diminished ovarian reserve induced by chronic unpredictable stress in C57BL/6 mice.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Gao L,Zhao F,Zhang Y,Wang W,Cao Q

PA5-50963 was used in Western Blotting to validate the effects of an 8-week chronic unpredictable stress (CUS) paradigm on the ovarian reserve and reproductive hormone secretion of C57BL/6 mice.

Wed Jan 01 00:00:00 UTC 2020

Diminished ovarian reserve induced by chronic unpredictable stress in C57BL/6 mice.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Gao L,Zhao F,Zhang Y,Wang W,Cao Q

PA5-50963 was used in Western Blotting to validate the effects of an 8-week chronic unpredictable stress (CUS) paradigm on the ovarian reserve and reproductive hormone secretion of C57BL/6 mice.

Wed Jan 01 00:00:00 UTC 2020

Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology.

Drug design, development and therapy

Gao L,Zhang Y,Xu H,Zhao F,Wang W

PA5-50963 was used in Western Blotting to verify the effects of modified Gengnianchun formula as a promising formula to treat DOR induced by chronic stress, and the PI3K-Akt pathway may play an essential role in this effect.