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产品信息
PA5-59909
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2641791
产品详细信息
Immunogen sequence: GDSELIGDLT QCVDCVIPPE GSLLQEALSG FAEAAGTTFV SLVVSGRVVA ATEGWWRLGT PEAVLLPWLV GSLPPQTARD YPVYL
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 88%.
靶标信息
FUZ is the human homolog of Drosophila fy protein and belongs to the fuzzy family. The fy gene of Drosophila encodes a novel four-pass transmembrane protein that plays two roles in the development of hairs on the Drosophila wing. The first is to specify the correct orientation of the hair by restricting its initiation to the distal vertex of the cell. The second role is to permit the development of just a single cell hair by maintaining the integrity of the F-actin and microtubule arrays that are required for hair development. In humans, the protein is involved in cytoskeleton function and cell polarity in epithelial cells. The human fuz gene is localized on chromosome 19q13.33.
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生物信息学
蛋白别名: fuzzy homolog; Protein fuzzy homolog
基因别名: FUZ; FY; NTD
UniProt ID: (Human) Q9BT04
Entrez Gene ID: (Human) 80199
establishment of planar polarity
neural tube closure
hair follicle development
negative regulation of cell proliferation
regulation of smoothened signaling pathway
embryonic body morphogenesis
protein transport
negative regulation of cell migration
nonmotile primary cilium assembly
cilium assembly
positive regulation of cilium assembly
embryonic skeletal system morphogenesis
negative regulation of canonical Wnt signaling pathway
negative regulation of neural crest formation
negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
