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产品信息
PA5-33556
产品规格
种属反应
Bat,
Bovine,
Dog,
Chicken,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 13 amino acid peptide from C-terminus of human FZD4 / Frizzled 4.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550936
靶标信息
FZD4 is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Frizzled 4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain.
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生物信息学
蛋白别名: 7-pass transmembrane receptor; CD344; CD344 antigen; cFz-4; frizzled 4, seven transmembrane spanning receptor; frizzled class receptor 4; frizzled family receptor 4; frizzled homolog 4; frizzled receptor 4; Frizzled-4; frizzled-4-like protein; frizzled-like protein 4; Fz-4; Fzd4; FzE4; mFz4; MGC34390; rFz4; WNT receptor frizzled-4
基因别名: CD344; EVR1; FEVR; Frizzled-4; FZ-4; FZ4; FZD4; FZD4S; FzE4; GPCR; hFz4; I79_022172
UniProt ID: (Human) Q9ULV1, (Chicken) Q9IA05, (Mouse) Q61088, (Rat) Q9QZH0
G-protein coupled receptor activity
protein binding
Wnt-protein binding
cytokine binding
PDZ domain binding
ubiquitin protein ligase binding
protein homodimerization activity
Wnt-activated receptor activity
protein heterodimerization activity
beta-amyloid binding
cytokine receptor activity
macromolecular complex binding
signal transducer activity
transmembrane signaling receptor activity
transmembrane signal receptor
vasculogenesis
G-protein coupled receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
sensory perception of sound
negative regulation of cell-substrate adhesion
Wnt signaling pathway
neuron differentiation
regulation of vascular endothelial growth factor receptor signaling pathway
locomotion involved in locomotory behavior
substrate adhesion-dependent cell spreading
extracellular matrix-cell signaling
progesterone secretion
positive regulation of JUN kinase activity
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
retina vasculature morphogenesis in camera-type eye
cerebellum vasculature morphogenesis
retinal blood vessel morphogenesis
cellular response to retinoic acid
luteinization
blood vessel development
cytokine-mediated signaling pathway
non-canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of neuron projection arborization
cellular response to leukemia inhibitory factor
signal transduction
cell surface receptor signaling pathway
multicellular organism development
biological_process
