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产品信息
PA5-111642
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2857052
产品详细信息
Immunogen sequence: CVGQNTSDGS GGPGGGPTAY PTAPYLPDLP FTAL
靶标信息
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
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生物信息学
蛋白别名: frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; rizzled 7
基因别名: FZD7; FzE3
UniProt ID: (Human) O75084
Entrez Gene ID: (Human) 8324
regulation of transcription, DNA-templated
G-protein coupled receptor signaling pathway
negative regulation of cell-substrate adhesion
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
stem cell population maintenance
neuron differentiation
T cell differentiation in thymus
substrate adhesion-dependent cell spreading
regulation of catenin import into nucleus
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of phosphorylation
negative regulation of ectodermal cell fate specification
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
somatic stem cell division
positive regulation of epithelial cell proliferation involved in wound healing
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
mesenchymal to epithelial transition
cellular response to retinoic acid
