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Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bovine, Bat, Hamster, Elephant, Panda, Rabbit, Opossum (100%); Platypus (94%); Chicken, Xenopus (89%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: frizzled 7, seven transmembrane spanning receptor; frizzled class receptor 7; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; mFz7; rizzled 7
基因别名: Frizzled-7; Fz7; FZD7; FzE3; I79_002993
UniProt ID: (Human) O75084, (Mouse) Q61090
Entrez Gene ID: (Dog) 488478, (Human) 8324, (Rabbit) 103348917, (Bovine) 524255, (Mouse) 14369, (Chinese hamster) 100766658, (Rat) 100360552