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FZD7 Antibody (PA5-92165) in WB
Western blot was performed using Anti-FZD7 Polyclonal Antibody (Product # PA5-92165) and a 70 kDa band corresponding to Frizzled-7 was observed across the cell lines tested except SK-BR-3 which is reported to be negative. Membrane enriched extracts (30 µg lysate) of Hep G2 (Lane 1), SW480 (Lane 2), HCT 116 (Lane 3), HT-29 (Lane 4), MDA-MB-231 (Lane 5), SK-BR-3 (Lane 6), HeLa (Lane 7) and MKN-45 (Lane 8) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0302BOX). Resolved proteins were then transferred onto a Nitrocel... View More
产品信息
PA5-92165
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human FZD7 (NP_0034981)
偶联物
形式
Liquid
浓度
0.52 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806397
产品详细信息
Immunogen sequence: MRDPGAAAPL SSLGLCALVL ALLGALSAGA GAQPYHGEKG ISVPDHGFCQ PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN FPVHGAGEIC VGQNTSDGSG GPGGGPTAYP TAPYLPDLPF TALPPGASDG RGRPAFPFSC PRQLKVPPYL GYRFLGERDC GAPCEPGRAN GLMYFKEEER RFARLWVGVW; Positive Samples: SW480, Mouse kidney; Cellular Location: Cell membrane, Membrane, Multi-pass membrane protein
靶标信息
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; mFz7; rizzled 7
基因别名: Fz7; FZD7; FzE3
UniProt ID: (Human) O75084, (Mouse) Q61090
Entrez Gene ID: (Human) 8324, (Mouse) 14369
regulation of transcription, DNA-templated
G-protein coupled receptor signaling pathway
negative regulation of cell-substrate adhesion
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
stem cell population maintenance
neuron differentiation
T cell differentiation in thymus
substrate adhesion-dependent cell spreading
regulation of catenin import into nucleus
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of phosphorylation
negative regulation of ectodermal cell fate specification
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
somatic stem cell division
positive regulation of epithelial cell proliferation involved in wound healing
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
mesenchymal to epithelial transition
cellular response to retinoic acid
signal transduction
cell surface receptor signaling pathway
multicellular organism development
Wnt signaling pathway
non-canonical Wnt signaling pathway
