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FZD7 Antibody (MA5-24378) in ICC/IF
Immunocytochemistry analysis of FZD7 in immersion fixed HEK293 human embryonic kidney cell line. Samples were incubated in FZD7 monoclonal antibody (Product # MA5-24378) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to the cell surface.
产品信息
MA5-24378
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
151143
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Frizzled-7 Gln33-Leu185
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2610095
产品详细信息
In direct ELISAs, no cross-reactivity with recombinant mouse Frizzled-1, -3, -4 or -8 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; mFz7; rizzled 7
基因别名: Fz7; FZD7; FzE3
UniProt ID: (Human) O75084, (Mouse) Q61090
Entrez Gene ID: (Human) 8324, (Mouse) 14369
regulation of transcription, DNA-templated
G-protein coupled receptor signaling pathway
negative regulation of cell-substrate adhesion
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
stem cell population maintenance
neuron differentiation
T cell differentiation in thymus
substrate adhesion-dependent cell spreading
regulation of catenin import into nucleus
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of phosphorylation
negative regulation of ectodermal cell fate specification
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
somatic stem cell division
positive regulation of epithelial cell proliferation involved in wound healing
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
mesenchymal to epithelial transition
cellular response to retinoic acid
signal transduction
cell surface receptor signaling pathway
multicellular organism development
Wnt signaling pathway
non-canonical Wnt signaling pathway
