Invitrogen

FZR1 Polyclonal Antibody

FZR1 Antibody in Immunohistochemistry (IHC)

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FZR1 Antibody (34-2000) in IHC

International journal of molecular sciences 2020 - Association of APC/C Cdh1 and PAH in HCC. ( A ) Expression box plot showing significant differential expression of Cdh1 in normal vs. tumor tissues using normal-tumor matched liver cancer patient RNAseq data from TCGA. p value < 0.05 was considered to be statistically significant. ( B ) Expression box plot showing significant differential expression of PAH in normal vs. tumor tissues using normal-tumor matc... View More

FZR1 Antibody in Western Blot, Immunocytochemistry, Immunoprecipitation (WB, ICC/IF, IP)

FZR1 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

FZR1 Antibody in Immunocytochemistry (ICC/IF)

FZR1 Antibody in Immunoprecipitation (IP)

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产品信息

34-2000

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

查看10篇已发表文章 10篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

查看4篇已发表文章 4篇已发表文章

免疫沉淀 (IP)

Assay-dependent

查看3篇已发表文章 3篇已发表文章

功能检测 (Functional)

查看1篇已发表文章 1篇已发表文章

其他PubMed (Misc)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide derived from the C-terminus of human FZR protein

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2533160

靶标信息

FZR is a 7WD domain family member implicated in cell cycle regulation of Drosophila and yeast. It has been shown that the over expression of fzr proteins increases natural killer cell-mediated cell death and as a result, suppresses tumor growth. The fzr protein is essential for cyclosome activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

CRL4^AMBRA1 is a master regulator of D-type cyclins.

Nature

Simoneschi D,Rona G,Zhou N,Jeong YT,Jiang S,Milletti G,Arbini AA,O'Sullivan A,Wang AA,Nithikasem S,Keegan S,Siu Y,Cianfanelli V,Maiani E,Nazio F,Cecconi F,Boccalatte F,Fenyö D,Jones DR,Busino L,Pagano M

34-2000 was used in Miscellaneous to reveal the molecular mechanism that controls the stability of D-type cyclins during cell-cycle progression, in development and in human cancer, and implicate AMBRA1 as a critical regulator of the RB pathway.

Thu Apr 01 00:00:00 UTC 2021

Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation.

Frontiers in oncology

Wang C,Li H,Wu L,Jiao X,Jin Z,Zhu Y,Fang Z,Zhang X,Huang H,Zhao L

34-2000 was used in Functional Assay to identify a novel CDK4 regulatory axis consisting of CCDC68 and ITCH, which suggest that CCDC68 is a promising target for the treatment of CRC.

Thu May 13 00:00:00 UTC 2021

E3 Ubiquitin Ligase APC/C^Cdh1 Regulation of Phenylalanine Hydroxylase Stability and Function.