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FZR1 Antibody (PA5-100535) in ICC/IF
Immunofluorescence analysis of FZR1 was performed using 70% confluent log phase A-431 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.01% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with FZR1 Polyclonal Antibody (Product # PA5-100535) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790), (1:... View More
产品信息
PA5-100535
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FZR1(Accession Q9UM11), corresponding to amino acid residues Q118-T168.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850044
产品详细信息
Antibody detects endogenous levels of total FZR1.
靶标信息
FZR is a 7WD domain family member implicated in cell cycle regulation of Drosophila and yeast. It has been shown that the over expression of fzr proteins increases natural killer cell-mediated cell death and as a result, suppresses tumor growth. The fzr protein is essential for cyclosome activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC20 homolog 1; CDC20-like 1b; CDC20-like protein 1; Cdh1/Hct1 homolog; cell division cycle 20 related 1; Fizzy-related protein homolog; Fzr; hCDH1
基因别名: AW108046; CDC20C; CDH1; FYR; FZR; FZR1; FZR2; HCDH; HCDH1; KIAA1242
UniProt ID: (Human) Q9UM11, (Mouse) Q9R1K5
Entrez Gene ID: (Human) 51343, (Mouse) 56371, (Rat) 314642
DNA repair
mitotic nuclear division
positive regulation of cell proliferation
anaphase-promoting complex-dependent catabolic process
G2 DNA damage checkpoint
regulation of meiotic nuclear division
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of protein catabolic process
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
lens fiber cell differentiation
protein K11-linked ubiquitination
negative regulation of cell aging
positive regulation of ubiquitin protein ligase activity
cellular response to DNA damage stimulus
cell cycle
