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NeoBiotechnologies
Fatty Acid Binding Protein 4 (FABP4) Monoclonal Antibody (FABP4/4422)
产品信息
2167-MSM2-P1
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
FABP4/4422
抗原
Recombinant fragment (around aa1-132) of human FABP4 protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: Human adipose tissue. Cellular Localization: Cytoplasm. Nucleus.
Specificity Comments: Fatty acid-binding proteins, designated FABPs, are a family of homologous, cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epidermis (E-FABP, also designated psoriasis-associated FABP or PA-FABP), muscle and heart (H-FABP, also designated mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP), myelin (M-FABP) and testis (T-FABP). The human A-FABP gene is organized into 4 exons, maps to chromosome 8q21.13, and encodes a 132 amino acid protein. A-FABP protein comprises approximately 1% of the total cytosolic protein in human adipose tissue.
靶标信息
FABP4 belongs to the fatty acid binding protein (FABP) family. FABPs contribute to the transport of fatty acids and other lipids in various cellular pathways. FABP4 is expressed in adipocytes, macrophages, monocyte-derived dendritic cells, and myoepithelial cells. It delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A-FABP; adipocyte fatty acid binding protein; Adipocyte lipid binding protein; Adipocyte lipid-binding protein; Adipocyte-type fatty acid-binding protein; ALBP; epididymis secretory protein Li 104; Fatty acid binding protein 4 adipocyte; fatty acid binding protein 4, adipocyte; Fatty acid-binding protein 4; Fatty acid-binding protein, adipocyte; HEL S 104
基因别名: A-FABP; AFABP; ALBP; aP2; FABP4; HEL-S-104
UniProt ID: (Human) P15090
Entrez Gene ID: (Human) 2167
cytokine production
negative regulation of protein kinase activity
transport
triglyceride catabolic process
cholesterol homeostasis
negative regulation of transcription, DNA-templated
positive regulation of inflammatory response
white fat cell differentiation
brown fat cell differentiation
cellular response to lithium ion
