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NeoBiotechnologies
Fatty Acid Binding Protein (Liver)/FABP1 Monoclonal Antibody (FABP1/3940)
Product Details
2168-MSM10-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
FABP1/3940
Immunogen
Human recombinant FABP1 protein fragment (around aa1-127).
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is stable for 24 months.
Positive Control: Liver or colon carcinoma tissues (IHC). Human kidney tissue lysate (WB). Cellular Localization: Cytoplasm. Nucleus.
Specificity Comments: Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epithelium (E-FABP, psoriasis-associated FABP, PA-FABP), striated muscle and heart (H-FABP, mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP or FABP1), myelin (M-FABP) and testis (T-FABP). FABP1 (L-FABP) expression is modulated by developmental, hormonal, dietary and pharmacological factors, and is required for cholesterol synthesis and metabolism.
Target Information
FABP1 encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fatty acid binding protein 1, liver; Fatty acid-binding protein 1; Fatty acid-binding protein, liver; L-FABP; Liver-type fatty acid-binding protein
Gene Aliases: FABP1; FABPL; L-FABP
UniProt ID: (Human) P07148
Entrez Gene ID: (Human) 2168
positive regulation of defense response to virus by host
positive regulation of cell proliferation
long-chain fatty acid transport
triglyceride catabolic process
positive regulation of fatty acid beta-oxidation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular lipid metabolic process
intestinal absorption
positive regulation of hydrolase activity
cellular response to hydrogen peroxide
cellular response to hypoxia
mitophagy in response to mitochondrial depolarization
xenophagy
cellular oxidant detoxification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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