Invitrogen

Fibrillin 1 Polyclonal Antibody

Fibrillin 1 Antibody in Western Blot (WB)

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Fibrillin 1 Antibody (PA5-27358) in WB

Western Blot using Fibrillin 1 Polyclonal Antibody (Product # PA5-27358). Sample (30 µg of whole cell lysate). Lane A: HeLa. 5% SDS PAGE. Fibrillin-1 antibody. Fibrillin 1 Polyclonal Antibody (Product # PA5-27358) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

Fibrillin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-27358

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化（石蜡） (IHC (P))

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免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 2679 and 2871 of Human Fibrillin 1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7, with 40% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2544834

产品详细信息

Recommended positive controls: HeLa.

Predicted reactivity: Mouse (92%), Rat (90%), Dog (92%), Pig (95%), Bovine (95%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule[3-7]. Fibrillin 1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Pro-Fibrotic Phenotype in a Patient with Segmental Stiff Skin Syndrome via TGF-β Signaling Overactivation.

International journal of molecular sciences

Fusco C,Nardella G,Augello B,Boccafoschi F,Palumbo O,Fusaro L,Notarangelo A,Barbano R,Parrella P,Annicchiarico G,De Meco C,Micale L,Graziano P,Castori M

PA5-27358 was used in Immunocytochemistry to undertake functional studies on a 12-year-old female with segmental stiff skin syndrome, to better explore the molecular and cellular mechanisms.

Mon Jul 20 00:00:00 UTC 2020

Pro-Fibrotic Phenotype in a Patient with Segmental Stiff Skin Syndrome via TGF-β Signaling Overactivation.

International journal of molecular sciences

Fusco C,Nardella G,Augello B,Boccafoschi F,Palumbo O,Fusaro L,Notarangelo A,Barbano R,Parrella P,Annicchiarico G,De Meco C,Micale L,Graziano P,Castori M

PA5-27358 was used in Immunocytochemistry to undertake functional studies on a 12-year-old female with segmental stiff skin syndrome, to better explore the molecular and cellular mechanisms.