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Fibrinogen gamma Antibody (PA5-21968) in ICC/IF
Fibrinogen gamma Polyclonal Antibody detects Fibrinogen gamma protein at cytoplasm by immunofluorescent analysis. Sample: HepG2 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Fibrinogen gamma stained by Fibrinogen gamma Polyclonal Antibody (Product # PA5-21968) diluted at 1:500. Blue: Fluoroshield with DAPI .
Product Details
PA5-21968
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 405 (P02679) of Fibrinogen gamma
Conjugate
Form
Liquid
Concentration
1.77 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_11154335
Product Specific Information
Recommended positive controls: HepG2, human plasma, HepG2 sup., mouse plasma, rat plasma.
Predicted reactivity: Mouse (85%), Rat (85%), Pig (84%), Bovine (82%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fibg; Fibrinogen gamma chain; Fibrinogen gamma-B chain; fibrinogen gamma-chain; fibrinogen, gamma polypeptide; Gamma'; gamma-fibrinogen; testicular tissue protein Li 70
Gene Aliases: 3010002H13Rik; AI256424; BOS_16250; FGG; PRO2061
UniProt ID: (Human) P02679, (Bovine) P12799, (Mouse) Q8VCM7, (Rat) P02680
Entrez Gene ID: (Human) 2266, (Bovine) 280792, (Mouse) 99571, (Rat) 24367
platelet degranulation
cell-matrix adhesion
signal transduction
blood coagulation
protein secretion
extracellular matrix organization
plasminogen activation
positive regulation of heterotypic cell-cell adhesion
fibrinolysis
cellular protein complex assembly
positive regulation of vasoconstriction
positive regulation of exocytosis
positive regulation of protein secretion
protein polymerization
response to calcium ion
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
blood coagulation, fibrin clot formation
positive regulation of peptide hormone secretion
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell apoptotic process
platelet activation
immune system process
hemostasis
innate immune response
inflammatory response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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