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Filamin A Antibody (IHC-00225) in IHC (P)
Detection of human Filamin by immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-Filamin (Product # IHC-00225) used at a dilution of 1:100. Detection: Red-fluorescent Alexa Fluor® 555 goat anti-rabbit IgG (Invitrogen) used at a dilution of 1:500.
产品信息
IHC-00225
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 1725 and 1775 of human Filamin A.
偶联物
形式
Liquid
浓度
50 µg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Orangutan, Monkey, Gorilla, Northern white-cheeked gibbon, Olive baboon, Crab-eating macaque and Dusky titi monkey
靶标信息
Filamin functions as a crosslinking protein forming a flexible link between two actin filaments. It is composed of two identical polypeptide chains each joined to the other at one end, with an actin binding site at the other. It is present in human platelets, lymphocytes, fibroblasts and smooth muscle actin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABP-280; actin binding protein 280; Actin-binding protein 280; alpha filamin; Alpha-filamin; Endothelial actin-binding protein; filamin 1; filamin A, alpha; Filamin-1; Filamin-A; Filamin1; FilaminA; FLN-A; Non-muscle filamin
基因别名: ABP-280; ABPX; CSBS; CVD1; FLN; FLN-A; FLN1; FLNA; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD
UniProt ID: (Human) P21333
Entrez Gene ID: (Human) 2316
G-protein coupled receptor binding
glycoprotein binding
signal transducer activity
protein binding
transcription factor binding
Rho GTPase binding
Ral GTPase binding
kinase binding
small GTPase binding
mu-type opioid receptor binding
Fc-gamma receptor I complex binding
protein homodimerization activity
poly(A) RNA binding
SMAD binding
Rac GTPase binding
actin filament binding
GTPase binding
cadherin binding involved in cell-cell adhesion
platelet degranulation
adenylate cyclase-inhibiting dopamine receptor signaling pathway
negative regulation of transcription from RNA polymerase I promoter
platelet activation
regulation of cell migration
actin cytoskeleton reorganization
cell junction assembly
protein localization to cell surface
negative regulation of protein catabolic process
cilium assembly
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription factor import into nucleus
negative regulation of apoptotic process
receptor clustering
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of sequence-specific DNA binding transcription factor activity
wound healing, spreading of cells
establishment of protein localization
protein stabilization
cytoplasmic sequestering of protein
actin crosslink formation
platelet aggregation
semaphorin-plexin signaling pathway
mitotic spindle assembly
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of integrin-mediated signaling pathway
