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Filamin A Antibody (PA5-96851) in IHC (P)
Immunohistochemistry analysis of Filamin A in paraffin-embedded human breast cancer using. Samples were incubated with Filamin A Polyclonal antibody (Product # PA5-96851) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-96851
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 2548-2647 of human Filamin A (NP_0011040261)
偶联物
形式
Liquid
浓度
1.4 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808653
产品详细信息
Positive Samples: HeLa, U-251MG, Mouse lung, Mouse spleen; Cellular Location: Cytoplasm, cell cortex, cytoskeleton
Immunogen sequence: GAPGPGPADA SKVVAKGLGL SKAYVGQKSS FTVDCSKAGN NMLLVGVHGP RTPCEEILVK HVGSRLYSVS YLLKDKGEYT LVVKWGDEHI PGSPYRVVVP
靶标信息
Filamin functions as a crosslinking protein forming a flexible link between two actin filaments. It is composed of two identical polypeptide chains each joined to the other at one end, with an actin binding site at the other. It is present in human platelets, lymphocytes, fibroblasts and smooth muscle actin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABP-280; actin binding protein 280; Actin-binding protein 280; alpha filamin; Alpha-filamin; dilated pupils 2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); filamin 1; filamin A, alpha; filamin, alpha; Filamin-1; Filamin-A; Filamin1; FilaminA; FLN-A; Non-muscle filamin
基因别名: ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; filamin-1; FLN; FLN-A; FLN1; FLNA; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD
UniProt ID: (Human) P21333
Entrez Gene ID: (Human) 2316, (Rat) 293860, (Mouse) 192176
G-protein coupled receptor binding
glycoprotein binding
signal transducer activity
protein binding
transcription factor binding
Rho GTPase binding
Ral GTPase binding
kinase binding
small GTPase binding
mu-type opioid receptor binding
Fc-gamma receptor I complex binding
protein homodimerization activity
poly(A) RNA binding
SMAD binding
Rac GTPase binding
actin filament binding
GTPase binding
cadherin binding involved in cell-cell adhesion
protein kinase C binding
protein complex binding
actin binding
epithelial to mesenchymal transition
adenylate cyclase-inhibiting dopamine receptor signaling pathway
biological_process
actin cytoskeleton organization
actin cytoskeleton reorganization
protein localization to cell surface
negative regulation of protein catabolic process
cilium assembly
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription factor import into nucleus
receptor clustering
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of sequence-specific DNA binding transcription factor activity
early endosome to late endosome transport
establishment of protein localization
protein stabilization
cytoplasmic sequestering of protein
actin crosslink formation
platelet aggregation
mitotic spindle assembly
negative regulation of transcription from RNA polymerase I promoter
cell projection organization
negative regulation of apoptotic process
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of integrin-mediated signaling pathway
platelet degranulation
platelet activation
regulation of cell migration
cell junction assembly
wound healing, spreading of cells
semaphorin-plexin signaling pathway
