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产品信息
PA5-29062
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 546 and 826 of Human Filamin A alpha 1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546538
产品详细信息
Recommended positive controls: 293T, A431.
Predicted reactivity: Mouse (98%), Rat (96%), Rabbit (98%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABP-280; actin binding protein 280; Actin-binding protein 280; alpha filamin; Alpha-filamin; Endothelial actin-binding protein; filamin A, alpha; Filamin-1; Filamin-A; FLN-A; Non-muscle filamin
基因别名: ABP-280; ABPX; CSBS; CVD1; FLN; FLN-A; FLN1; FLNA; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD
UniProt ID: (Human) P21333
Entrez Gene ID: (Human) 2316
G-protein coupled receptor binding
glycoprotein binding
signal transducer activity
protein binding
transcription factor binding
Rho GTPase binding
Ral GTPase binding
kinase binding
small GTPase binding
mu-type opioid receptor binding
Fc-gamma receptor I complex binding
protein homodimerization activity
poly(A) RNA binding
SMAD binding
Rac GTPase binding
actin filament binding
GTPase binding
cadherin binding involved in cell-cell adhesion
platelet degranulation
adenylate cyclase-inhibiting dopamine receptor signaling pathway
negative regulation of transcription from RNA polymerase I promoter
platelet activation
regulation of cell migration
actin cytoskeleton reorganization
cell junction assembly
protein localization to cell surface
negative regulation of protein catabolic process
cilium assembly
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription factor import into nucleus
negative regulation of apoptotic process
receptor clustering
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of sequence-specific DNA binding transcription factor activity
wound healing, spreading of cells
establishment of protein localization
protein stabilization
cytoplasmic sequestering of protein
actin crosslink formation
platelet aggregation
semaphorin-plexin signaling pathway
mitotic spindle assembly
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of integrin-mediated signaling pathway
