Invitrogen

Fumarase Polyclonal Antibody

Fumarase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Fumarase Antibody (PA5-18745) in IHC (P)

Immunohistochemistry analysis of Fumarase in human skeletal muscle. Samples were incubated with Fumarase polyclonal antibody (Product # PA5-18745) using a dilution of 3.75 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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产品信息

PA5-18745

应用

建议稀释比

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免疫印迹 (WB)

0.01-0.03 µg/mL

免疫组化（石蜡） (IHC (P))

3.75 µg/mL

产品规格

种属反应

Human

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide sequence (HPNDHVNKSQSSND) corresponding to the internal amino acids of FH (aa 176-190).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_11006491

产品详细信息

This antibody is predicted to react with canine, mouse and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

靶标信息

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

仅用于科研。不用于诊断过程。未经明确授权不得转售。