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Furin Antibody (MA5-38340) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Furin in paraffin-embedded human placenta tissue using Furin Monoclonal Antibody (Product # MA5-38340) diluted at 1:100. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is... View More
产品信息
MA5-38340
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1C3
抗原
A synthesized peptide derived from human Furin
偶联物
形式
Liquid
浓度
1.2 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 150mM NaCl
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2898255
产品详细信息
This antibody has been tested in direct-ELISA
靶标信息
Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dibasic processing enzyme; Dibasic-processing enzyme; FES upstream region; Furin; furin (paired basic amino acid cleaving enzyme); furin, membrane associated receptor protein; PACE; Paired basic amino acid residue-cleaving enzyme; proprotein convertase subtilisin/kexin type 3
基因别名: FUR; FURIN; PACE; PCSK3; SPC1
UniProt ID: (Human) P09958
Entrez Gene ID: (Human) 5045
signal peptide processing
transforming growth factor beta receptor signaling pathway
aging
cell proliferation
negative regulation of endopeptidase activity
protein processing
peptide hormone processing
viral life cycle
viral protein processing
extracellular matrix disassembly
extracellular matrix organization
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
collagen catabolic process
nerve growth factor processing
negative regulation of low-density lipoprotein particle receptor catabolic process
nerve growth factor production
negative regulation of nerve growth factor production
negative regulation of transforming growth factor beta1 production
secretion by cell
regulation of protein catabolic process
peptide biosynthetic process
cellular protein metabolic process
regulation of low-density lipoprotein particle receptor biosynthetic process
positive regulation of membrane protein ectodomain proteolysis
regulation of endopeptidase activity
