Invitrogen

G3BP2 Polyclonal Antibody

G3BP2 Antibody in Immunohistochemistry (IHC)

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G3BP2 Antibody (PA5-53797) in IHC

Immunohistochemical staining of G3BP2 in human cerebellum, cerebral cortex, skin and testis using G3BP2 Polyclonal Antibody (Product # PA5-53797) (A) shows similar protein distribution across tissues to an independent G3BP2 Polyclonal Antibody (B).

Product Image Gallery

G3BP2 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of G3BP2 demonstrates antibody specificity. Immunohistochemical analysis of G3BP2 using anti-G3BP2 Polyclonal Antibody (Product # PA5-53797), shows significant staining of G3BP2 in human cerebral cortex and shows minimal or weak staining in human skin tissues. The relative expression levels of G3BP2 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-53797

应用

建议稀释比

已发表文章

免疫印迹 (WB)

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免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫沉淀 (IP)

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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human G3BP2. Recombinant protein control fragment (Product #RP-91850).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2641802

产品详细信息

Immunogen sequence: KNLEELEEKS TTPPPAEPVS LPQEPPKPRV EAKPEVQSQP PRVREQRPRE RPGFPPRGPR PGRGDMEQND S

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.

靶标信息

G3BP2 gene ontology annotations related to this gene include stress granule assembly.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Circular RNA Cwc27 contributes to Alzheimer's disease pathogenesis by repressing Pur-α activity.

Cell death and differentiation

Song C,Zhang Y,Huang W,Shi J,Huang Q,Jiang M,Qiu Y,Wang T,Chen H,Wang H

PA5-53797 was used in Immunoprecipitation to suggest significant functional consequences of a circRNA-protein interaction, that circCwc27, by associating with the regulatory protein Pur-α, may act as a crucial player in AD pathogenesis and represent a promising AD therapeutic target with clinical translational potential.

Tue Feb 01 00:00:00 UTC 2022

Human Insulin Growth Factor 2 mRNA Binding Protein 2 Increases MicroRNA 33a/b Inhibition of Liver ABCA1 Expression and Alters Low-Density Apolipoprotein Levels in Mice.

Molecular and cellular biology

Yang M,Gallo-Ebert C,Hayward M,Liu W,McDonough V,Nickels JT

PA5-53797 was used in Western Blotting to support the hypothesis that IGF2BP2 has an important role in maintaining lipid homeostasis through its modulation of ABCA1 expression, as its overexpression or loss leads to dyslipidemia.

Wed Jul 29 00:00:00 UTC 2020

生物信息学

蛋白别名: G3BP-2; GAP SH3 domain-binding protein 2; GTPase activating protein (SH3 domain) binding protein 2; Ras GTPase-activating protein-binding protein 2; Ras-GTPase activating protein SH3 domain-binding protein 2

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基因别名: G3BP2; KIAA0660

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UniProt ID: (Human) Q9UN86

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Entrez Gene ID: (Human) 9908

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功能

nucleotide binding protein binding receptor signaling complex scaffold activity poly(A) RNA binding RNA metabolism protein nucleic acid metabolism protein

参与通路

cytoplasmic sequestering of NF-kappaB Ras protein signal transduction mRNA transport