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GABBR1 Antibody (PA5-27725) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of GABBR1 was performed in SH-SY5Y cells fixed in 4% paraformaldehyde at RT for 15 min. Green: GABBR1 Polyclonal Antibody (Product # PA5-27725) diluted at 1:500. Red: SOX2 protein stained by SOX2 antibody. Blue: Hoechst 33342 staining.
产品信息
PA5-27725
应用
建议稀释比
已发表文章
产品规格
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 268 and 532 of Human GABA B Receptor 1
偶联物
形式
Liquid
浓度
0.43 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545201
产品详细信息
Recommended positive controls: PC-3, U87-MG, SK-N-SH, C8D30.
Predicted reactivity: Mouse (98%), Rat (98%), Pig (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
