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GABPA Antibody (PA5-27735) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of GABPA was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: GABPA Polyclonal Antibody (Product # PA5-27735) diluted at 1:1000. Red: phalloidin, a cytoskeleton marker. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
产品信息
PA5-27735
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 111 and 311 of Human GABPA
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545211
产品详细信息
Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Mouse (97%), Rat (99%), Xenopus laevis (82%), Chicken (86%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GA binding protein transcription factor alpha subunit 60kDa; GA binding protein transcription factor, alpha subunit 60kDa; GA-binding protein alpha chain; GABP subunit alpha; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor 2 alpha subunit; Nuclear respiratory factor 2 subunit alpha; Transcription factor E4TF1-60
基因别名: E4TF1-60; E4TF1A; GABPA; NFT2; NRF2; NRF2A; RCH04A07
UniProt ID: (Human) Q06546
Entrez Gene ID: (Human) 2551
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription regulatory region DNA binding
protein heterodimerization activity
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
transcription from RNA polymerase II promoter
mitochondrion organization
cell differentiation
negative regulation of megakaryocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
