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产品信息
MA5-15419
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
8C1B10
抗原
Purified recombinant fragment of human GABPA (aa120-190) expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_10977231
产品详细信息
MA5-15419 targets GABPA in indirect ELISA, IF ICC and WB applications and shows reactivity with Human and mouse samples.
The MA5-15419 immunogen is purified recombinant fragment of human GABPA (aa120-190) expressed in E. Coli.
.
MA5-15419 detects GABPA which has a predicted molecular weight of approximately 51kDa.
靶标信息
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GA binding protein transcription factor alpha subunit 60kDa; GA binding protein transcription factor, alpha subunit 60kDa; GA repeat binding protein alpha; GA-binding protein alpha chain; GA-binding protein alpha-subunit; GABP subunit alpha; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor 2 alpha subunit; Nuclear respiratory factor 2 subunit alpha; Transcription factor E4TF1-60
基因别名: E4TF1-60; E4TF1A; GABPA; GABPalpha; NFT2; NRF2; NRF2A; RCH04A07
UniProt ID: (Human) Q06546, (Mouse) Q00422
Entrez Gene ID: (Human) 2551, (Mouse) 14390
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription regulatory region DNA binding
protein heterodimerization activity
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
transcription from RNA polymerase II promoter
mitochondrion organization
cell differentiation
negative regulation of megakaryocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
