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Immunogen sequence: GRDENSVELT MAEGPYKIIL TARPFRLDLL EDRSLLLSVN ARGLLEFEHQ RAPRVSQGSK DPAEGDGAQP EETPRDG
This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease.
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Protein Aliases: Alpha-glucosidase 2; Glucosidase II subunit alpha; Neutral alpha-glucosidase AB
Gene Aliases: G2AN; GANAB; GIIA; GLUII; KIAA0088
UniProt ID: (Human) Q14697
Entrez Gene ID: (Human) 23193
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