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GAPDHS Antibody (PA5-87928) in IHC (P)
Immunohistochemistry analysis of GAPDHS in paraffin-embedded mouse testis. Samples were incubated with GAPDHS Polyclonal antibody (Product # PA5-87928) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-87928
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 179-408 of human GAPDHS (NP_0551791)
偶联物
形式
Liquid
浓度
4.49 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804511
产品详细信息
Immunogen sequence: ASDHISAGAQ RVVISAPSPD APMFVMGVNE NDYNPGSMNI VSNASCTTNC LAPLAKVIHE RFGIVEGLMT TVHSYTATQK TVDGPSRKAW RDGRGAHQNI IPASTGAAKA VTKVIPELKG KLTGMAFRVP TPDVSVVDLT CRLAQPAPYS AIKEAVKAAA KGPMAGILAY TEDEVVSTDF LGDTHSSIFD AKAGIALNDN FVKLISWYDN EYGYSHRVVD LLRYMFSRDK; Positive Samples: HT-1080, U-251MG, SW620, MCF-7, Mouse liver, Rat testis; Cellular Location: Cytoplasm
靶标信息
Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway, the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. Because GAPDH is a protein expressed in large amounts and which is required at all times for important "house keeping" functions, levels of GAPDH mRNA are often measured and used as standards in studies of mRNA expression. Increasingly, scientists are making use of specific antibodies to GAPDH in comparable studies of levels of protein expression. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease, and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington's disease. Associations with actin and tubulin have also been reported. The protein may also have a role in the regulation of apoptosis, and interestingly migrates from the cytoplasm into the nucleus when cells become apoptotic.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis secretory protein Li 278; GAPDH S; GAPDH-2; glyceraldehyde-3-phosphate dehydrogenase type 2; Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; Spermatogenic glyceraldehyde-3-phosphate dehydrogenase
基因别名: Gapd-s; GAPD2; GAPDH-2; GAPDH2; GAPDHS; GAPDS; HEL-S-278; HSD-35; HSD35
UniProt ID: (Human) O14556, (Rat) Q9ESV6, (Mouse) Q64467
Entrez Gene ID: (Human) 26330, (Rat) 66020, (Mouse) 14447
