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GAS2L1 Antibody (PA5-102586) in IHC (P)
Immunohistochemistry analysis of GAS2L1 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with GAS2L1 polyclonal antibody (Product # PA5-102586) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-102586
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GAS2L1(Accession Q99501), corresponding to amino acid residues C624-R674.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851988
产品详细信息
Antibody detects endogenous levels of total GAS2L1.
靶标信息
The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 or caspase-7) at Asparagine 278 during apoptosis. The cleaved form of Gas2 dramatically induces the re-arrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated, but when hyperphosphorylated it will accumulate at membrane ruffles, indicating Gas2 involvement in that process. Gar22 (Gas2-related protein on chromosome 22), also designated growth arrest-specific protein 2-like 1 (Gas2-like1), belongs to the Gas2 family and contains one CH (calponinhomo-logy) domain. It is thought to be involved in the cross-linking of microtubules and microfilaments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GAS2-like protein 1; GAS2-related protein; GAS2-related protein on chromosome 22; growth arrest-specific 2 like 1; Growth arrest-specific protein 2-like 1
基因别名: 4930500E24Rik; D0Jmb1; GAR22; GAS2L1; TU-71.1
UniProt ID: (Human) Q53EN7, (Mouse) Q8JZP9
Entrez Gene ID: (Human) 10634, (Mouse) 78926, (Rat) 360973
microtubule bundle formation
negative regulation of microtubule depolymerization
cell cycle arrest
cellular response to starvation
negative regulation of gene expression
negative regulation of cell growth
negative regulation of erythrocyte differentiation
regulation of cell cycle
cellular response to thyroid hormone stimulus
