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GATSL2 Antibody (PA5-72114) in IHC (P)
Immunohistochemistry analysis of GATSL2 in paraffin-embedded human brain tissue. Samples were incubated with GATSL2 polyclonal antibody (Product # PA5-72114) using a dilution of 1:250 for 15 min at room temperature followed by Leica Bond Polymer Refine Detection. Tissue was fixed with formaldehyde at room temperature. Heat induced epitope retrieval was performed by EDTA buffer (pH 9 0).
产品信息
PA5-72114
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 25-51 amino acids from the N-terminal region of human GATSL2
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2717968
靶标信息
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cellular arginine sensor for mTORC1 protein 2; Cytosolic arginine sensor for mTORC1 subunit 2; GATL2; GATS protein-like 1; GATS protein-like 2; GATS-like protein 1; GATS-like protein 2
基因别名: CASTOR2; GATSL1; GATSL2
UniProt ID: (Human) A6NHX0
Entrez Gene ID: (Human) 729438
