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Immunogen sequence: HDTADWKDLN LKFVLQVYRD YYLTGDQNFL KDMWPVCLAV MESEMKFDKD HDGLIENGGY ADQTYDGWVT TGPSAYCGGL WLAAVAVMVQ MAALCGAQDI QDKFSSILSR GQEAYERLLW NGRYYNYDSS SRPQSRSVMS DQCA
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 95%.
Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3.2.1.45; Beta-glucocerebrosidase 2; Beta-glucosidase 2; Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; Cholesteryl-beta-glucosidase GBA2; glucosidase, beta (bile acid) 2; Glucosylceramidase 2; NLGase; Non-lysosomal cholesterol glycosyltransferase; Non-lysosomal galactosylceramidase; Non-lysosomal glucosylceramidase; Non-lysosomal glycosylceramidase
基因别名: AD035; GBA2; KIAA1605; NLGase; SPG46
UniProt ID: (Human) Q9HCG7
Entrez Gene ID: (Human) 57704