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产品信息
2638-MSM2-P1
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
VDBP/4482
抗原
Recombinant fragment (around aa 35-175) of human GC protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: Human liver, kidney or pancreas. Cellular Localization: Secreted.
Specificity Comments: Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.
靶标信息
GC (vitamin D-binding protein) is involved in vitamin D transport/storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
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生物信息学
蛋白别名: DBP; DBP-maf; DBP/ VDBG; epididymis secretory protein Li 51; Gc; Gc globulin; Gc protein-derived macrophage activating factor; Gc-globulin; Gc-MAF; Group specific component vitamin D binding protein; Group-specific component; group-specific component (vitamin D binding protein); hDBP; V VDB; VDB; Vitamin D binding alpha globulin; vitamin D-binding alpha-globulin; Vitamin D-binding protein; Vitamin D-binding protein-macrophage activating factor
基因别名: DBP; DBP/GC; GC; Gc-MAF; GcMAF; GRD3; HEL-S-51; VDBG; VDBP
UniProt ID: (Human) P02774
Entrez Gene ID: (Human) 2638
