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产品信息
H00002645-D01P
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GCK (AAH01890.1, 1 a.a. approximately 465 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MLDDRARMEA AKKEKVEQIL AEFQLQEEDL KKVMRRMQKE MDRGLRLETH EEASVKMLPT YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEEGQWS VKTKHQMYSI PEDAMTGTAE MLFDYISECI SDFLDKHQMK HKKLPLGFTF SFPVRHEDID KGILLNWTKG FKASGAEGNN VVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDHQC EVGMIVGTGC NACYMEEMQN VELVEGDEGR MCVNTEWGAF GDSGELDEFL LEYDRLVDES SANPGQQLYE KLIGGKYMGE LVRLVLLRLV DENLLFHGEA SEQLRTRGAF ETRFVSQVES DTGDRKQIYN ILSTLGLRPS TTDCDIVRRA CESVSTRAAH MCSAGLAGVI NRMRESRSED VMRITVGVDG SVYKLHPSFK ERFHASVRRL TPSCEITFIE SEEGSGRGAA LVSAVACKKA CMLGQ
靶标信息
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP:D-hexose 6-phosphotransferase; GC kinase; Glucokinase; glucokinase (hexokinase 4); glucokinase variant 3; hexokinase 4; hexokinase D, pancreatic isozyme; Hexokinase type IV; Hexokinase-4; Hexokinase-D; HK IV; HK4; MEKKK 2
基因别名: FGQTL3; GCK; GK; GLK; Gls006; GLUKA; HHF3; HK4; HKIV; Hlb62; HXKP; LGLK; MODY2; RNGK2
UniProt ID: (Human) P35557, (Rat) P17712, (Mouse) P52792
Entrez Gene ID: (Human) 2645, (Rat) 24385, (Mouse) 103988
magnesium ion binding
glucokinase activity
protein binding
ATP binding
glucose binding
fructokinase activity
mannokinase activity
protein phosphatase binding
ADP binding
nucleotide binding
hexokinase activity
kinase activity
transferase activity
phosphotransferase activity, alcohol group as acceptor
kinase
cellular glucose homeostasis
glycogen biosynthetic process
fructose 2,6-bisphosphate metabolic process
glycolytic process
regulation of glycolytic process
NADP metabolic process
positive regulation of cytosolic calcium ion concentration
regulation of glucose transport
glucose transport
second-messenger-mediated signaling
positive regulation of insulin secretion
negative regulation of epinephrine secretion
cellular response to insulin stimulus
cellular response to glucose starvation
glucose homeostasis
regulation of potassium ion transport
cellular response to leptin stimulus
negative regulation of gluconeogenesis
positive regulation of glycogen biosynthetic process
positive regulation of glycolytic process
carbohydrate phosphorylation
regulation of insulin secretion
glucose 6-phosphate metabolic process
detection of glucose
lipid homeostasis
canonical glycolysis
calcium ion import
glucose metabolic process
response to glucose
positive regulation of phosphorylation
carbohydrate metabolic process
phosphorylation
