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产品信息
MA5-15878
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4G6
抗原
Purified recombinant fragment of human GCK expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11154130
产品详细信息
MA5-15878 targets GCK in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15878 immunogen is purified recombinant fragment of human GCK expressed in E. Coli. .
MA5-15878 detects GCK which has a predicted molecular weight of approximately 52kDa.
靶标信息
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
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生物信息学
蛋白别名: ATP:D-hexose 6-phosphotransferase; GC kinase; Glucokinase; glucokinase (hexokinase 4); hexokinase D, pancreatic isozyme; Hexokinase type IV; Hexokinase-4; Hexokinase-D; HK IV; HK4; MEKKK 2
基因别名: FGQTL3; GCK; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2
UniProt ID: (Human) P35557
Entrez Gene ID: (Human) 2645
cellular glucose homeostasis
glycogen biosynthetic process
fructose 2,6-bisphosphate metabolic process
glycolytic process
regulation of glycolytic process
NADP metabolic process
positive regulation of cytosolic calcium ion concentration
regulation of glucose transport
glucose transport
second-messenger-mediated signaling
positive regulation of insulin secretion
negative regulation of epinephrine secretion
cellular response to insulin stimulus
cellular response to glucose starvation
glucose homeostasis
regulation of potassium ion transport
cellular response to leptin stimulus
negative regulation of gluconeogenesis
positive regulation of glycogen biosynthetic process
positive regulation of glycolytic process
carbohydrate phosphorylation
regulation of insulin secretion
glucose 6-phosphate metabolic process
detection of glucose
lipid homeostasis
canonical glycolysis
calcium ion import
