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Product Details
PA5-97774
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Chorion-specific transcription factor GCMb protein (156-451AA)
Conjugate
Form
Liquid
Concentration
3 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2812389
Target Information
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chorion-specific transcription factor GCMb; GCM motif protein 2; glial cells missing 2; Glial cells missing homolog 2; glial cells missing homolog b; glide/gcm protein homolog; hGCMb; RP3-417M14.3
Gene Aliases: GCM2; GCMB; hGCMb
UniProt ID: (Human) O75603
Entrez Gene ID: (Human) 9247, (Rat) 291047
transcription from RNA polymerase II promoter
cellular calcium ion homeostasis
multicellular organism development
cellular phosphate ion homeostasis
gliogenesis
positive regulation of transcription from RNA polymerase II promoter
parathyroid gland development
regulation of transcription, DNA-templated
biological_process
cell differentiation
negative regulation of apoptotic process
cellular response to organic substance
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