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Product Details
PA5-98712
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase protein (203-402AA)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2813325
Target Information
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1, 6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-1,6-N-acetylglucosaminyltransferase; beta-1,6-N-acetylglucosaminyltransferase 2; glucosaminyltransferase, I-branching enzyme; I beta-1,6-N-acetylglucosaminyltransferase; I-branching enzyme; IGNT; Ii blood group; Large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase; N-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
Gene Aliases: 5330430K10Rik; bA360O19.2; bA421M1.1; CCAT; CTRCT13; GCNT2; GCNT2C; GCNT5; IGNT; IGnTA; IGnTB; IGnTC; II; NACGT1; NAGCT1; ULG3
UniProt ID: (Human) Q8N0V5, (Mouse) P97402
Entrez Gene ID: (Human) 2651, (Mouse) 14538
glycosaminoglycan biosynthetic process
protein glycosylation
transforming growth factor beta receptor signaling pathway
multicellular organism development
positive regulation of cell proliferation
posttranscriptional regulation of gene expression
positive regulation of epithelial to mesenchymal transition
negative regulation of cell-substrate adhesion
positive regulation of cell migration
positive regulation of heterotypic cell-cell adhesion
maintenance of lens transparency
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
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