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GDF5 Antibody (PA5-28815) in IHC (P)
GDF5 Polyclonal Antibody detects GDF5 protein at cytosol on human breast cancer by immunohistochemical analysis. Sample: Paraffin-embedded breast cancer. GDF5 Polyclonal Antibody (Product # PA5-28815) dilution: 1:250. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-28815
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region within amino acids 437 and 501 of Human GDF5
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546291
产品详细信息
Recommended positive controls: 293T, A431, H1299, NIH-3T3, JC.
Predicted reactivity: Mouse (100%), Xenopus laevis (100%), Pig (100%), Rabbit (100%), Chicken (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP-14; Bone morphogenetic protein 14; brachypodism; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP-1; GDF-5; Growth/differentiation factor 5; H-GDF-5; LAP-4; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; Radotermin
基因别名: BDA1C; BMP-14; BMP14; Bp; brp; Cdmp-1; CDMP1; Gdf-5; GDF5; LAP-4; LAP4; OS5; SYM1B; SYNS2
UniProt ID: (Human) P43026, (Mouse) P43027
Entrez Gene ID: (Human) 8200, (Mouse) 14563
chondrocyte differentiation
transforming growth factor beta receptor signaling pathway
SMAD protein import into nucleus
cell-cell signaling
positive regulation of pathway-restricted SMAD protein phosphorylation
embryonic limb morphogenesis
positive regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
forelimb morphogenesis
hindlimb morphogenesis
growth
regulation of multicellular organism growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of neuron differentiation
cell development
negative regulation of epithelial cell proliferation
SMAD protein signal transduction
chondroblast differentiation
mitophagy in response to mitochondrial depolarization
negative regulation of mesenchymal cell apoptotic process
transmembrane receptor protein serine/threonine kinase signaling pathway
BMP signaling pathway
cartilage development
