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产品信息
PA5-53358
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2641937
产品详细信息
Immunogen sequence: RYVFDISALE KDGLLGAELR ILRKKPSDTA KPAAPGGGRA AQLKLSSCPS GRQPASLLDV RSVPGLDGSG WEVFDIWKLF RNFKNSAQLC LELEAWERGR AVDL
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
靶标信息
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP-14; Bone morphogenetic protein 14; brachypodism; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP-1; GDF-5; growth differentiation factor 5; Growth/differentiation factor 5; H-GDF-5; LAP-4; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; Radotermin
基因别名: BDA1C; BMP-14; BMP14; Bp; brp; Cdmp-1; CDMP1; Gdf-5; GDF5; LAP-4; LAP4; OS5; SYM1B; SYNS2
UniProt ID: (Human) P43026, (Mouse) P43027
Entrez Gene ID: (Human) 8200, (Rat) 252835, (Mouse) 14563
chondrocyte differentiation
transforming growth factor beta receptor signaling pathway
SMAD protein import into nucleus
cell-cell signaling
positive regulation of pathway-restricted SMAD protein phosphorylation
embryonic limb morphogenesis
positive regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
forelimb morphogenesis
hindlimb morphogenesis
growth
regulation of multicellular organism growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of neuron differentiation
cell development
negative regulation of epithelial cell proliferation
SMAD protein signal transduction
chondroblast differentiation
mitophagy in response to mitochondrial depolarization
negative regulation of mesenchymal cell apoptotic process
transmembrane receptor protein serine/threonine kinase signaling pathway
BMP signaling pathway
cartilage development
