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产品信息
PA1-18366
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant human GDNF (aa 78-211).
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1074599
产品详细信息
Reconstitute in 50 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
靶标信息
GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Astrocyte-derived trophic factor; ATF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF; mGDNF; neurotrophic factor
基因别名: AI385739; ATF1; ATF2; GDNF; gndf; HFB1-GDNF; HSCR3
UniProt ID: (Human) P39905, (Mouse) P48540, (Rat) Q07731
Entrez Gene ID: (Human) 2668, (Mouse) 14573, (Rat) 25453
metanephros development
ureteric bud development
branching involved in ureteric bud morphogenesis
neural crest cell migration
organ induction
postsynaptic membrane organization
mesenchymal to epithelial transition involved in metanephros morphogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
nervous system development
peripheral nervous system development
cell proliferation
positive regulation of cell proliferation
response to wounding
regulation of gene expression
postganglionic parasympathetic fiber development
neuron differentiation
peristalsis
neuron projection development
positive regulation of monooxygenase activity
negative regulation of neuron apoptotic process
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mRNA stabilization
enteric nervous system development
sympathetic nervous system development
regulation of dopamine uptake involved in synaptic transmission
ureteric bud formation
regulation of morphogenesis of a branching structure
cellular response to dexamethasone stimulus
regulation of ureteric bud formation
positive regulation of ureteric bud formation
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
male gonad development
midbrain development
retina development in camera-type eye
MAPK cascade
signal transduction
adult locomotory behavior
positive regulation of dopamine secretion
negative regulation of apoptotic process
positive regulation of GTPase activity
regulation of stem cell differentiation
