Invitrogen

GDNF Polyclonal Antibody

查看其他17个GDNF抗体

产品信息

PA1-24827

应用

建议稀释比

已发表文章

中和实验 (Neu)

2.6 µg/mL

-

抑制试剂 (IA)

2.6 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant, full length human GDNF protein expressed in E. coli.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_794354

产品详细信息

Neutralization: The ND50 is 2.6 µg/mL.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Astrocyte-derived trophic factor; ATF; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF

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基因别名: ATF1; ATF2; GDNF; HFB1-GDNF; HSCR3

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UniProt ID: (Human) P39905

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Entrez Gene ID: (Human) 2668

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Ras guanyl-nucleotide exchange factor activity receptor binding protein binding growth factor activity protein homodimerization activity

MAPK cascade metanephros development branching involved in ureteric bud morphogenesis neural crest cell migration organ induction postsynaptic membrane organization mesenchymal to epithelial transition involved in metanephros morphogenesis signal transduction nervous system development positive regulation of cell proliferation adult locomotory behavior regulation of gene expression postganglionic parasympathetic fiber development peristalsis neuron projection development positive regulation of monooxygenase activity positive regulation of dopamine secretion negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter mRNA stabilization enteric nervous system development sympathetic nervous system development regulation of dopamine uptake involved in synaptic transmission ureteric bud formation regulation of morphogenesis of a branching structure positive regulation of ureteric bud formation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of branching involved in ureteric bud morphogenesis regulation of stem cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand