Invitrogen

GDNF Polyclonal Antibody

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GDNF Antibody (PA1-9524) in WB

Cell cycle (Georgetown, Tex.) 2019 - Published figure using GDNF polyclonal antibody (Product # PA1-9524) in Western Blot

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产品信息

PA1-9524

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

1:50-1:500

酶联免疫吸附实验 (ELISA)

1:500-1:2,000

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Chicken / IgY

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide based on the human GDNF protein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

IgY fraction

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2111385

产品详细信息

PA1-9524 detects GDNF in human, mouse and rat samples.

PA1-9524 has been successfully used in Western blot, ELISA, and Immunohistochemistry procedures. By Western blot, PA1-9524 detects a 24 kDa protein representing GDNF.

PA1-9524 immunogen is a synthetic peptide based on the human GDNF protein.

Store product at 4ºC for up to one week, and -20ºC for long term storage.

靶标信息

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Reduction of cortical parvalbumin-expressing GABAergic interneurons in a rodent hyperoxia model of preterm birth brain injury with deficits in social behavior and cognition.

Development (Cambridge, England)

Scheuer T,dem Brinke EA,Grosser S,Wolf SA,Mattei D,Sharkovska Y,Barthel PC,Endesfelder S,Friedrich V,Bührer C,Vida I,Schmitz T

PA1-9524 was used in Western Blot to demonstrate that neonatal oxidative stress can lead to decreased interneuron density and to psychiatric symptoms.

Fri Oct 15 00:00:00 UTC 2021

LncRNA MIAT overexpression reduced neuron apoptosis in a neonatal rat model of hypoxic-ischemic injury through miR-211/GDNF.

Cell cycle (Georgetown, Tex.)

Li EY,Zhao PJ,Jian J,Yin BQ,Sun ZY,Xu CX,Tang YC,Wu H

Published figure using GDNF polyclonal antibody (Product # PA1-9524) in Western Blot

Tue Jan 01 00:00:00 UTC 2019

生物信息学

蛋白别名: Astrocyte-derived trophic factor; ATF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF; mGDNF; neurotrophic factor

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基因别名: AI385739; ATF1; ATF2; GDNF; gndf; HFB1-GDNF; HSCR3

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UniProt ID: (Human) P39905, (Mouse) P48540, (Rat) Q07731

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Entrez Gene ID: (Human) 2668, (Mouse) 14573, (Rat) 25453

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功能

Ras guanyl-nucleotide exchange factor activity receptor binding protein binding growth factor activity protein homodimerization activity transforming growth factor beta receptor binding glial cell-derived neurotrophic factor receptor binding

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