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产品信息
H00002709-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GJB5 (AAH04379, 1 a.a. approximately 273 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MNWSIFEGLL SGVNKYSTAF GRIWLSLVFI FRVLVYLVTA ERVWSDDHKD FDCNTRQPGC SNVCFDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREV QEKRHREAHG ENSGRLYLNP GKKRGGLWWT YVCSLVFKAS VDIAFLYVFH SFYPKYILPP VVKCHADPCP NIVDCFISKP SEKNIFTLFM VATAAICILL NLVELIYLVS KRCHECLAAR KAQAMCTGHH PHGTTSSCKQ DDLLSGDLIF LGSDSHPPLL PDRPRDHVKK TIL
靶标信息
The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.1, Cx31.1 or Gap junction beta-5 protein, is a 271 amino acid protein that is predominantly expressed in skin with lower expression in testis. Expression of connexin 31.1 is required for normal placental development in mice. Down-regulation of the connexin 31.1 gene correlates with head and neck squamous cell carcinomas (HNSCC) and therefore it may be a potential therapeutic target.
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生物信息学
蛋白别名: Connexin-31.1; Cx31.1; Gap junction beta-5 protein; gap junction protein, beta 5 (connexin 31.1); gap junction protein, beta 5, 31.1kDa; gap junctional protein cx31.1
基因别名: CX31.1; GJB5
UniProt ID: (Human) O95377
Entrez Gene ID: (Human) 2709
