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This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: anterior digit pattern deformity; brachyphalangy; extra toes; GLI-Kruppel family member GLI3; GLI3 form of 190 kDa; GLI3 full length protein; GLI3 full-length protein; GLI3-190; GLI3FL; glioma-associated oncogene family zinc finger 3; oncogene GLI3; polydactyly Nagoya; Transcriptional activator GLI3; zinc finger protein GLI3
基因别名: ACLS; add; AI854843; AU023367; Bph; GCPS; GLI3; GLI3-190; GLI3FL; PAP-A; PAPA; PAPA1; PAPB; Pdn; PHS; PPDIV; Xt
UniProt ID: (Human) P10071, (Mouse) Q61602
Entrez Gene ID: (Human) 2737, (Rat) 140588, (Mouse) 14634