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GLP1R (extracellular) Antibody (AGR-021-200UL) in ICC/IF
Expression of Glucagon-like peptide 1 receptor in rat pancreatic islet cells - Cell surface detection of Glucagon-like peptide 1 receptor in live intact rat RIN-5F pancreatic islet cells. A. Cells were stained with Anti-GLP1R (extracellular) Antibody (#AGR-021), (1:100), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Cell nuclei were visualized with the membrane-permeable DNA dye H... View More
产品信息
AGR-021-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KYLYEDEG(S)WTRNS, corresponding to amino acid residues 288-301 of rat GLP1R, 2nd extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Glucagon-like peptide-1(9-36)amide and GLP-1(9-37) are the forms of GLP-1 that result from the rapid degradation of the active forms of the peptide (GLP-1(7-36)amide and GLP-1(7-37)) by the enzyme dipeptidyl peptidase-IV (DPP-IV, also known as CD26 or adenosine deaminase binding protein). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GLP-1 receptor; GLP-1-R; GLP-1R; GLP-I receptor; GLP1 receptor; Glucagon-like peptide 1 receptor; glucagon-like peptide-1 receptor; pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1; seven transmembrane helix receptor
基因别名: Glip; GLP-1; GLP-1-R; GLP-1R; GLP1R; GLP1Rc; Glpr; RATGL1RCP
UniProt ID: (Human) P43220, (Mouse) O35659, (Rat) P32301
Entrez Gene ID: (Human) 2740, (Mouse) 14652, (Rat) 25051
response to stress
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
learning or memory
regulation of heart contraction
cAMP-mediated signaling
positive regulation of blood pressure
regulation of insulin secretion
cellular response to glucagon stimulus
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
memory
feeding behavior
positive regulation of cell proliferation
associative learning
response to glucose
insulin secretion
positive regulation of insulin secretion
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of cell differentiation
positive regulation of heart contraction
positive regulation of transcription from RNA polymerase II promoter
hormone secretion
release of sequestered calcium ion into cytosol
regulation of calcium ion transport
positive regulation of glucose import
