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产品信息
PA5-142974
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence CLQAKDGISVKGAN.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933614
产品详细信息
Additional Information: The immunizing peptide represents part of the cytoplasmic domain. The antibody is not expected to cross-react with other glycine receptor alpha proteins.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
靶标信息
GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GLRA; Glra2; glycine receptor; Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; glycine receptor, alpha 1 subunit; gra1
基因别名: GLRA1; Glyr; GLYRA1; HKPX1; nmf11; oscillator; ot; spasmodic; spd; STHE
UniProt ID: (Human) P23415, (Mouse) Q64018, (Rat) P07727
Entrez Gene ID: (Human) 2741, (Mouse) 14654, (Rat) 25674
protein binding
zinc ion binding
glycine binding
extracellular-glycine-gated chloride channel activity
transmitter-gated ion channel activity
taurine binding
extracellular ligand-gated ion channel activity
chloride channel activity
extracellular-glycine-gated ion channel activity
ligand-gated ion channel
action potential
startle response
regulation of respiratory gaseous exchange by neurological system process
ion transport
chloride transport
muscle contraction
neuropeptide signaling pathway
acrosome reaction
visual perception
adult walking behavior
ion transmembrane transport
regulation of membrane potential
neuromuscular process controlling posture
protein homooligomerization
protein heterooligomerization
negative regulation of transmission of nerve impulse
synaptic transmission, glycinergic
righting reflex
inhibitory postsynaptic potential
cellular response to amino acid stimulus
cellular response to zinc ion
cellular response to ethanol
response to alcohol
chloride transmembrane transport
positive regulation of acrosome reaction
transport
anion transport
chemical synaptic transmission
regulation of respiratory gaseous exchange
neuromuscular process
