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GLRX Antibody (PA5-47451) in WB
Western blot analysis of GLRX in NIH-3T3 mouse embryonic fibroblast cell line and C2C12 mouse myoblast cell line. Samples were incubated in GLRX polyclonal antibody (Product # PA5-47451) using a dilution of 0.5 µg/mL followed by a HRP‚conjugated Anti-Goat IgG secondary antibody. A specific band was detected for Glutaredoxin 1 at approximately 12 kDa (as indicated).
产品信息
PA5-47451
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant mouse Glutaredoxin 1 Met1-Leu107
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2576816
产品详细信息
This antibody detects endogenous human and mouse Glutaradoxin in Western blots.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH. First recovered in E.coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase via two redox-active cysteine residues. The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12-kDa dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: glutaredoxin (thioltransferase); glutaredoxin 1; glutaredoxin 1 (thioltransferase); Glutaredoxin-1; Glutaredoxin1; Grx 1; MGC117; MGC117407; Thioltransferase 1; Thioltransferase-1; Thioltransferase1; TTase 1; TTase-1; TTase1
基因别名: C86710; D13Wsu156e; Glrx; Glrx1; Grx; Grx1; TTase
UniProt ID: (Mouse) Q9QUH0
Entrez Gene ID: (Mouse) 93692
transport
positive regulation of insulin secretion
cell redox homeostasis
positive regulation of membrane potential
positive regulation of exocytosis
oxidation-reduction process
positive regulation of cell adhesion molecule production
cellular response to estradiol stimulus
positive regulation of NIK/NF-kappaB signaling
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
positive regulation of sodium ion transmembrane transporter activity
