Invitrogen

GLUT2 Polyclonal Antibody

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GLUT2 Antibody (720238) in WB

Western blot analysis was performed on membrane enriched cell extracts (30 µg lysate) of HepG2 (Lane 1), Caco2 (Lane 2), HEK-293 (Lane 3), NIH/3T3 (Lane 4), C2C12 (Lane 5), PC-12 (Lane 6). The blots were probed with Anti-GLUT2 Rabbit Polyclonal antibody (Product # 720238, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A ~ 57 kDa band corresponding to GLUT2 was observed in all cell lines tested. Known quantit... View More

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产品信息

720238

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptides corresponding to Human GLUT2 (aa 73-86, 264-281, 498-511)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2, with 0.1% BSA, 30% glycerol

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2633212

产品详细信息

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.

This antibody is predicted to react with Monkey, Pig, Horse and Cat

靶标信息

Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in the gene that encode this protein cause Fanconi-Bickel syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Antidiabetic effect of sciadonic acid on type 2 diabetic mice through activating the PI3K-AKT signaling pathway and altering intestinal flora.

Frontiers in nutrition

Chen L,Jiang Q,Lu H,Jiang C,Hu W,Yu S,Xiang X,Tan CP,Feng Y,Zhang J,Li M,Shen G

720238 was used in Western Blotting to suggest that SA could reshape the structural composition of intestinal microbes, activate the PI3K/AKT/GLUT2 pathway, improve insulin resistance, and decrease blood glucose levels.

Wed Jan 11 00:00:00 UTC 2023

Early weaning induces short- and long-term effects on pancreatic islets in Wistar rats of both sexes.

The Journal of physiology

Pietrobon CB,Miranda RA,Bertasso IM,Mathias PCF,Bonfleur ML,Balbo SL,Reis MAB,Latorraca MQ,Arantes VC,de Oliveira E,Lisboa PC,de Moura EG

720238 was used in Western Blotting to investigate the mechanisms by which glycaemic homeostasis is altered in EW models through evaluations of insulin secretion and its signalling pathway in offspring.

Sat Feb 01 00:00:00 UTC 2020

The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding.

Cell metabolism

Benegiamo G,Mure LS,Erikson G,Le HD,Moriggi E,Brown SA,Panda S

720238 was used in Western Blotting to study the mechanism by which feeding and fasting drive rhythmic gene expression for physiological adaptation to daily rhythm in nutrient availability.

Tue Feb 06 00:00:00 UTC 2018

生物信息学

蛋白别名: glucose transporter 2; Glucose transporter type 2, liver; GLUT-2; liver-type glucose transporter; solute carrier family 2 (facilitated glucose transporter), member 2; Solute carrier family 2, facilitated glucose transporter member 2

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基因别名: AI266973; Glut-2; GLUT2; GTT2; SLC2A2

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UniProt ID: (Human) P11168, (Mouse) P14246

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Entrez Gene ID: (Human) 6514, (Mouse) 20526, (Rat) 25351

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功能

insulin receptor binding glucose transmembrane transporter activity hexose transmembrane transporter activity dehydroascorbic acid transporter activity D-glucose transmembrane transporter activity transporter activity sugar:proton symporter activity transmembrane transporter activity substrate-specific transmembrane transporter activity

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