Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 3
GNA13 Antibody (MA5-44800) in IHC (P)
Immunohistochemistry analysis of GNA13 in paraffin-embedded mouse colon tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with GNA13 Monoclonal antibody (Product # MA5-44800) using a dilution of 1:400 for 1 hour at room t... View More
产品信息
MA5-44800
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE63-76
抗原
Recombinant protein within human GNA13 aa 278-377/377.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2931257
靶标信息
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: G alpha 13; G alpha-13; G-protein subunit alpha-13; Galpha 13; guanine nucleotide binding protein (G protein), alpha 13; guanine nucleotide binding protein, alpha 13; Guanine nucleotide-binding protein subunit alpha-13
基因别名: AU024132; AU043124; G13; Galpha13; Gna-13; GNA13
UniProt ID: (Human) B2R977, (Mouse) P27601, (Rat) Q6Q7Y5
Entrez Gene ID: (Human) 10672, (Mouse) 14674, (Rat) 303634
GTPase activity
signal transducer activity
protein binding
GTP binding
G-protein beta/gamma-subunit complex binding
type 1 angiotensin receptor binding
D5 dopamine receptor binding
metal ion binding
nucleotide binding
G-protein coupled receptor binding
guanyl nucleotide binding
heterotrimeric G-protein
patterning of blood vessels
in utero embryonic development
movement of cell or subcellular component
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Rho protein signal transduction
regulation of cell shape
cell differentiation
platelet activation
regulation of cell migration
activation of phospholipase D activity
angiogenesis
G-protein coupled receptor signaling pathway
small GTPase mediated signal transduction
intracellular signal transduction
metabolic process
