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产品信息
PA5-76657
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human GNAO1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720384
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686O0962; G alpha o; GNAO 1; Go alpha; GO2-q chimeric G-protein; GTP-binding protein alpha o; GTP-binding protein alpha-o subunit; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha O polypeptide 1; Guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2
基因别名: alphaO; AW050213; EIEE17; G-ALPHA-o; Galphao; Gna0; GNAO; GNAO1; HLA-DQB1; RATBPGTPC
UniProt ID: (Human) P09471, (Rat) P59215, (Mouse) P18872
Entrez Gene ID: (Human) 2775, (Rat) 50664, (Mouse) 14681
GTPase activity
signal transducer activity
GTP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
mu-type opioid receptor binding
GTPase activating protein binding
metal ion binding
corticotropin-releasing hormone receptor 1 binding
protein binding
GDP binding
protein complex binding
nucleotide binding
guanyl nucleotide binding
heterotrimeric G-protein
protein folding
muscle contraction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
dopamine receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
aging
locomotory behavior
regulation of heart contraction
forebrain development
neuron projection development
response to cytokine
response to drug
response to hydrogen peroxide
response to morphine
positive regulation of GTPase activity
negative regulation of calcium ion transport
G-protein coupled receptor signaling pathway
metabolic process
cellular process
response to organonitrogen compound
response to organic cyclic compound
signal transduction
